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Microsoft has made a $44.6 billion bid for Yahoo, an aggressive move by the software giant to gain market share on the Internet and compete with Google. Microsoft and Yahoo have talked about merging for years. This time, a hostile but very rich offer could seal the deal.

Arizona Sen. John McCain reinforced his lead among GOP candidates with big wins in California and New York, while results show Democrats Hillary Clinton and Barack Obama with a long fight ahead to win the nomination. Political analysts Stephanie Cutter and Sarah Taylor sort through Super Tuesday results.

Actor and former Tennessee Sen. Fred Thompson dropped out of the Republican presidential contest Tuesday. He had said he needed to win in South Carolina, but finished third there. Melissa Block talks with Rich Galen, former senior adviser to the Thompson campaign.

An autopsy is scheduled Wednesday for Heath Ledger, a day after the 28-year-old actor was found dead at his New York apartment. Ledger's Oscar nomination for Brokeback Mountain was the highlight of a career filled with promise.

In Kenya, a funeral for opposition members killed in the violent political crisis dissolved in fumes of tear gas as police battled stone-throwing youths. The latest violence came as former U.N. Chief Kofi Annan began talks to try to resolve the post-election stalemate that threatens what had been East Africa's most stable nation.

Former President Bill Clinton is brushing off criticism that his campaign-trail rhetoric unfairly targets Sen. Barack Obama. Obama has complained that he's not sure who he is running against: Sen. Hillary Clinton, her husband, or both.

In their latest debate, Barack Obama and Hillary Clinton clashed over comments Obama made about former President Ronald Reagan. Obama called Reagan a "transformational president." David Folkenflik looks at the political wisdom of a Democratic candidate invoking the memory of a Republican president.

The Centers for Disease Control and Prevention wants adults to remember that vaccines aren't just for kids. Whooping cough, shingles, tetanus, and several other illnesses are still big problems in the U.S., mostly because adults aren't getting the shots they need.

Conversations with voters in South Carolina reinforce suspicions that Sen. Barack Obama is having trouble attracting support from white Democrats. He has strong support among blacks, who make up about half the state's Democrats.

President Bush is preparing to address the nation in the final State of the Union address of his presidency. White House Counselor Ed Gillespie explains what to expect — and what not to expect — from the speech. Gillespie also provides an update on the bipartisan economic stimulus package currenltly working its way through Congress.